In December 2020, the IOG launched Government Science and Innovation in the New Normal (GSINN), a multi-year, collaborative research initiative designed to support medium-term planning for the federal science and innovation departments and agencies, and provide an in-depth examination of the evolving relationship among science, innovation and society. GSINN organizes an examination of this evolving relationship into eight themes: Equity, Diversity and Inclusion; Global Research Collaboration and Infrastructure; Inclusive Innovation; Interdisciplinary, Indigenous and Other Ways of Knowing; Mission-Driven Research and Innovation; Science Communications, Outreach, and Public Engagement; Skills and Knowledge; and, Trust, Integrity and Science Ethics. This GSINN Literature Review synthesizes findings on the implications of the COVID19 pandemic on the science and innovation enterprise, and draws links between the ideas raised by leading edge scholars and institutions and the eight themes at the focus of this project.